Hope for Lyme disease? New vaccine targets ticks

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Erol Fikrig has spent 10 years pursuing a vaccine that will take a new approach to protecting people from Lyme disease, a growing scourge in the United States: He doesn't want to target it, not the pathogen. it's the ticks that infect them. Then, at a June 2019 conference in Killarney, Ireland He overheard immunologist Drew Weissman at the University of Pennsylvania. Describing a lesser-known technology at the time: the messenger RNA (mRNA) vaccine. In the blink of an eye,

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Figric saw the way forward. A Yale School of Medicine infectious disease doctor captured Weissman and asked if the technology could be effective against the deer ticks that transmit Lyme disease in the United States. “I wanted to do that,” Figrig said of Weissman.MRNA technology is now known for delivering vaccines against COVID-19. And this week, MRNA technology has achieved another milestone with a preventive Lyme trial announced by the partnership launched in Ireland.

This is the first vaccine. [It is intended for humans] against infectious diseases that are not targeted towards pathogens," said Figrig. The mRNA vaccine administered to guinea pigs The tick bite becomes red and inflamed. Ticks do not eat well. fall out early And often it is unable to transmit the bacteria that cause Lyme. Researchers hope that one day the vaccine will work the same way in humans.Ruth Montgomery, a cellular immunologist at Yale, said it was "a beautiful study" who was not involved in the work.